基本情况
姓名：宋化灿
性别：男
出生年月：1959-04
籍贯：山东
职位：
博士、教授，有机化学专业博士生导师
联系方式
电话：+86-020-84110918
传真：暂未填写
邮箱：yjhxhc@mail.sysu.edu.cn
通讯地址：广东省广州市永利集团3044noc登录入口化学与化学工程学院
邮编：510275
个人网站：暂未填写
教育经历
1978年2月—1982年1月，山东大学化学系有机化学专业，本科；
1993年9月—1996年7月，永利集团3044noc登录入口化学系有机化学专业，博士。
工作经历
1996年6月永利集团3044noc登录入口有机化学专业博士毕业留校任教至今，先后任讲师、副教授、教授。先后于1998和1999年赴美国Brigham Young University和2001—2002年赴台湾大学做博士后研究各一年。主讲过《有机化学》、《有机分析》、《有机化学实验》、《物理有机化学》等课程。公开发表研究论文60余篇。
1982年1月—1993年8月，郑州轻工业学院化工系任教；
1996年7月—1998年8月，永利集团3044noc登录入口化学系，副教授；
1998年9月—1999年8月，美国Brigham Young University，博士后；
1999年8月—2001年9月，永利集团3044noc登录入口化学院，副教授；
2001年9月—2002年8月，台湾大学化学系，博士后；
2002年8月—2004年3月，永利集团3044noc登录入口化学院，副教授；
2004年4月至今，永利集团3044noc登录入口化学院，教授，博士生导师。
讲授课程
《物理有机化学》（本科生，36学时）；
《物理有机化学》（研究生，60学时）。
科研方向
药物设计与合成、有机发光材料。
科研项目
1、顺德科技局产学研结合项目“水基喷柒产品技术的研究与应用”，2007-2009。
2、广东省教育部产学研结合项目“高性能氯化聚丙烯改性树脂的研发” 2009-2010。
3、广东省教育部产学研结合项目“低硫低碳制革工艺和助剂的研究开发”， 2010-2011。
4、广东中烟公司项目“主要烟用香料转移行为对卷烟品质的影响及其应用研究” 2009-2011。
5、广东省科技计划重点项目“广东凉茶的数字化质量控制技术研究”，2011-2012。
6、长江生命科技国际有限公司项目（香港）“用于抗癌药物活性测试的化合物的合成”，2010-2012。
获奖情况
暂无资料
论著一览
《物理有机化学》英柏宁、宋化灿，化学工业出版社，2010年。
相关成果
04年前主要论文：
1. Ning Su, Jerald S. Bradshaw, Xian Xin Zhang, Hua-Can Song, Paul B. Savage, Guaoping Xue, Krzysztof, Krakowiak, and Reed M. Izatt, Synthesis and metal ion complexation of novel 8-Hydroxyquinoline-containing diaza-18-crown-6 ligands and analogs, J. Org. Chem. 1999, 64, 8855
2. Jerald S. Bradshaw, Hua-Can Song, Guoping Xue, R. Todd Bronson, Joseph A. Chiara, and Reed, M. Izatt, Synthesis of diazadi(and tri)thiacrown ethers containing two 5-substituent(or 2-methyl)-8-hydroxyquinoline side arms Supramol. Chem. 2001, 13, 499.
3. Hua-Can, Song, Yi-Wen Chen, Xiang-Li Zheng, Bai-Ning Ying, Study on second harmonic generation of 10-hydrocarbylacridiones, Spectrochimica Acta Part A, 2001, 57 , 1717.
4. Guo-ping Xue, Jerald S. Bradshaw, Hua-Can Song, R. Todd, Bronson, Paul B. Savage, Reed, M. Izatt, A convenient synthesis and preliminary photophysical study of novel fluoroionophores: macrocyclic polyamines containing two dansylaminoethyl side arms. Tetrahedron, 2001, 57, 87.
5. Hua-Can Song, Rui Jiang Jin, Xiang Li Zheng, Bai Ning Ying. Study on second harmonic generation of 9-(substituted-benzylidene-10-methyl)-9,10-dihydroacridines, Spectrochimica Acta Part A, 2001, 57, 2729.
6. Hua-Can Song, Jearld S. Bradshaw, Yi-Wen Chen, et al. Synthesis of diazadithiacrwn ethers containing two 8-hydroxyquinoline side arms, ARKIVOC, 2001 ISSUE in Honor of Prof. Miha Tisler. 2001, 2, Part3, ms 0116.
7. Hua-Can Song, Yi-Wen Chen, Ji-Guo Song, Paul B. Sarage, Guo-Ping Xue, Jeseph A. Chiara, Krzysztof E. Krakowoak, Reed M. Izatt and Jerald S. Bradshaw. New diazdi (and tri) thia-21-crown-7 ethers containing 8-hydroxyquinoline side arms, J. Heterocyclic Chem. 2001, 38, 1369.
8. Hua-Can Song, Jerald S. Bradshaw, Yi-Wen Chen, Guo-Ping Xue, Wei-Ming Li, Krzysztof E. Krakowoak, Paul B. Sarage, Zun-le Xu and Reed M. Izatt. Synthesis of new crown ethers containing appended pyridine, 10-hydroxybenzoquinoline, 8-hydroxyquinoline and 2-amino-1-hydroxybiphenyl sidearms, Supramol. Chem. 2002, 14, 263.
9. Chin-Fa Lee, Liu Chin-Yuan, Hua-Can Song, et al, Bidirectional iterative synthesis of alternating benzene-furan oligomers towards molecular wires, Chem. Commun. 2002, 2824.
10. Hua-Can Song, Ping Huan, Bai-Ning Ying, Molecular complexes of antipsychotic pharmaceutical parent molecule phenothiazine and unsaturated acid anhydrides. Spectrochimica Acta Part A, 2003, 59, 1509.
11. Hua-Can Song, Wei-Ming Li, Guang-Rong Liu, Zun-Le Xu. Study on the optical properties of 4,4’-bis-(2-(substituted-styryl))-biphenyl and 1,4-bis-(2-(substituted-styryl)) benzene Spectrochimica Acta Part A, 2003, 59, 2041.
12. Hua-Can Song, Yi-Wen Chen, Jun-Hua Yao, Zun-Le Xu, Jeaald S. Bradshaw and Reed M. Izatt. Syntheses of diazadithiacrown ethers containing appended coumarin or 1-aminonaphthene as sidearms J. Heterocyclic Chem. 2003, 40, 475.
13. Huang, Z.-L.; Li, N.; Sun, Y.-F.; Wang, H.-Z.; Song, H.-C.; Xu, Z.-L. Synthesis and photophysical characterization of two new coumarinyl-based organic molecules with two-photon induced fluorescent emission, J. Mol. Structure, 2003, 657, 343.
14. Hua-Can Song, Huan Wen, Wei-Ming Li, Study on the second-order optical behavior of 4-(substituted-benzylidene)-2-phenyl-4H-oxazol-5-one, Spectrochimica Acta Part A. 2004, 60, 1587.
近期主要论文：
1. 1-(1-Arylethylidene)Thiosemicarbazide derivatives: A new class of tyrosinase inhibitors, Bioorganic and Medicinal Chemistry, 2008, 1096;
2. Synthesis and cytotoxic activities of 1-benzylidine substituted β-carboline derivatives, Bioorganic & Medicinal Chemistry Letters, 2008, 6558;
3. Synthesis and in vitro cytotoxic evaluation of novel 3,4,5-trimethoxyphenyl substituted β-carboline derivatives,European Journal Medicinal Chemistry,2008, 533;
4. Synthesis and biological evaluation of helicid analoguesas novel acetylcholinester as einhibitors, European Journal Medicinal Chemistry, 2008, 166;
5. The synthesis and preliminary optical study of 1-alkyl-2,4,5-triphenylimidazole derivatives, Dyes and Pigments, 2008, 17;
6. Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors, Bioorganic & Medicinal Chemistry Letters, 2008, 6490;
7. A class of potent tyrosinase inhibitors: Alkylidenethiosemicarbazide compounds, European Journal Medicinal Chemistry, 2009, 1773;
8. Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl β-aldehyde ketone derivatives,European Journal Medicinal Chemistry, 2009, 1737;
9. Discovery of 4-functionalized phenyl-O-β-d-glycosides as a new class of mushroom tyrosinase inhibitors,Bioorganic & Medicinal Chemistry Letters, 2009, 6157;
10. Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors,European Journal of Medicinal Chemistry, 2009, 1737;
11. Synthesis and evaluation of 5-benzylidene(thio)barbiturate-β-d-glycosides as mushroom tyrosinase inhibitors,Bioorganic & Medicinal Chemistry Letters, 2009, 4055;
12. Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities, European Journal of Medicinal Chemistry, 2009, 4235;
13. Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl β-aldehyde ketone derivatives,European Journal of Medicinal Chemistry, 2009, 1737;
14. Synthesis and optical behaviors of 2-(9-phenanthrenyl)-, 2-(9-anthryl)-, and 2-(1-pyrenyl)-1-alkylimidazole homologues, Spectrochimica Acta Part A, 2009, 233;
15. Biological evaluations of novel vitamin C esters as mushroom tyrosinase inhibitors and antioxidants, Food Chemistry, 2009, 381;
16. Synthesis of 4-[(diethylamino)methyl]phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyryl cholinesterase, Bioorganic & Medicinal Chemistry Letters,2010, 3254;
17. Synthesisandcytotoxicevaluationof N-benzylatedquaternary b-carboline amino acid ester conjugates, European Journal of Medicinal Chemistry, 2010, 1515;
18. Synthesis and preliminary optical study of 1,3,4-oxadiazole derivatives containing imidazole units, Dyes and Pigments, 2010, 249;
19. Synthesis of novel β-carbolines with efficient DNA-binding capacity and potent cytotoxicity, Bioorganic & Medicinal Chemistry Letters, 2010, 3876;
20. Design, synthesis and 3D-QSAR of β-carboline derivatives as potent antitumor agents, European Journal of Medicinal Chemistry, 2010,2503;
21. Synthesis, cytotoxic activities and DNA binding properties of β-carboline derivatives, European Journal of Medicinal Chemistry, 2010, 4740;
22. Synthesis and cytotoxic evaluation of 1-carboxamide and 1-amino side chain substituted β-carbolines,European Journal of Medicinal Chemistry, 2010, 5513;
23. Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors, European Journal of Medicinal Chemistry, 2010, 639;
24. α-Glucosidase and α-amylase inhibitory activities of guava leaves, Food Chemistry, 2010, 6;
25. Design, synthesis and biological evaluation of 3-(4-halophenyl)-3-oxopropanal and their derivatives as novel antibacterial agents, Chem. Pharm. Bull. 2010, 1127;
26. Rational design and synthesis of 4-O-substituted phenylmethylene thiosemi- carbazones as novel tyrosinase inhibitors, Chem. Pharm. Bull. 2010, 752;
27, Design, synthesis and evaluation of difunctionalized 4-hydroxybenzaldehyde derivatives as novel cholinesterase inhibitors, Chem. Pharm. Bull. 2010, 1216;
28. Synthesis and biological evaluation of novel B-Carbolines as potent cytotoxic and DNA intercalatingagents,Chem. Pharm. Bull. 2010, 901.
