讲授课程

1. 本科生：《化学学习与研究》、《无机化学》、《无机化学实验》、《普通化学》、《大学化学实验》、《现代化学》（逸仙班）、《化学生物学实验》、《今日化学》、《化学前沿》（基础学科拔尖学生培养实验班）
2. 研究生：《配位化学》、《化学前沿进展》

科研方向

1. DNA/RNA生物大分子结构识别及其生物功能调控。
2. 金属多吡啶配合物为基元的光电分子器件研究。
3. 金属抗肿瘤、抗菌药物。
4. 生物荧光成像试剂。

科研项目

承担国家自然科学基金（包括国家杰出青年科学基金项目、重点国际(地区)合作研究项目、重大研究计划集成项目、重大研究计划培育项目、面上项目、青年项目）、科技部国家重点基础研究发展计划（973计划）课题、教育部新世纪优秀人才支持计划项目、教育部创新团队项目（核心成员）、教育部科学技术研究重点项目、教育部高校博士点基金博导类课题、教育部留学回国人员科研启动基金、广东省基金团队项目（核心成员）、广东省自然科学基金自由项目、广东省高等学校功能分子工程卓越中心基础研究团队项目、国家重点实验室开放基金、永利集团3044noc登录入口高校基本科研业务费交叉学科培育项目、永利集团3044noc登录入口青年教师重点培育计划等30多项课题研究。

科研成绩

已在《Chem. Soc. Rev》、《Coord. Chem. Rev》、《Nature Chemistry》、《Nat. Commun.》、《Proc. Natl, Acad. Sci. USA》、《J. Am. Chem. Soc.》、《Angew. Chem. Int. Ed.》、《Adv. Mater.》、《Biomaterials》等国际期刊发表第一作者或通讯作者SCI论文248篇，论文被引用15500多次， H-index 69。申请中国发明专利18件, 授权14件。参编专著教材8部。目前担任中国化学会化学生物学学科委员会委员、中国感光学会光化学与光生物专业委员会委员、中国稀土学会稀土材料化学与生物技术交叉专业委员会委员、广东省化学会常务理事、广东省化学会化学生物学专业委员会主任委员、生物药光动力治疗技术国家地方联合工程研究中心（福州大学）学术委员会委员、理论有机化学与功能分子教育部重点实验室（湖南科技大学）学术委员会副主任委员、药物化学与分子诊断教育部重点实验室（河北大学）学术委员会委员、《Scientific Reports》编委（2018-至今）、《Journal of Inorganic Biochemistry》编委（2018-2021）、《RSC Chemical Biology》客座编辑（2023）。

获奖情况

2001年，中国高校自然科学奖二等奖（第九完成人）
2005年，中国化学会“青年化学奖”
2006年，教育部“新世纪优秀人才支持计划” 
2006年，广东省高等学校“千百十工程”人才培养计划（校级）
2007年，永利集团3044noc登录入口化学与化工学院“53奖教金”
2011年，广东省科学技术奖一等奖（第二完成人）
2011年，永利集团3044noc登录入口校级教学名师
2012年，国家自然科学奖二等奖（第三完成人）
2012年，永利集团3044noc登录入口第七届校级教学成果奖一等奖（第一完成人）
2012年，永利集团3044noc登录入口第七届校级教学成果奖一等奖（第四完成人）
2012年，南粤优秀教师
2013年，永利集团3044noc登录入口化学与化工学院“芙兰励教奖教金”
2014年，广东省教育教学成果奖（高等教育）一等奖（第一完成人）
2014年，广东省教育教学成果奖（高等教育）二等奖（第四完成人）
2014年，永利集团3044noc登录入口化学与化工学院“施开良教学管理创新奖”
2014年，宝钢优秀教师奖
2015年，国家杰青
2015年，广东特支计划“百千万工程领军人才”
2017年，永利集团3044noc登录入口第八届校级教学成果奖二等奖（第一完成人）
2017年，永利集团3044noc登录入口第八届校级教学成果奖一等奖（第五完成人）
2018年，广东省教育教学成果奖（高等教育）一等奖（第五完成人）
2018年，高等教育国家级教学成果奖二等奖（第四完成人）
2018年，高等教育国家级教学成果奖二等奖（第五完成人）
2019年，永利集团3044noc登录入口“科苑奖教金”
2019年，永利集团3044noc登录入口“93奖教金”
2020年，中国化学会高级会员
2020年，永利集团3044noc登录入口“科苑奖教金”
2020年，永利集团3044noc登录入口“93奖教金”
2021年，永利集团3044noc登录入口“芙兰励教奖教金科研奖”
2021年，爱思维尔2020年度中国高被引学者
2022年，爱思维尔2021年度中国高被引学者
2022年，全球前2%顶尖科学家（World Top 2% Scientists，斯坦福大学排名）
2022年，RSC Horizon Prize (Dalton Division)
2022年，永利集团3044noc登录入口“科苑奖教金”
2023年，爱思维尔2022年度中国高被引学者
2023年，全球前2%顶尖科学家（World Top 2% Scientists，斯坦福大学排名）
2024年，爱思维尔2023年度中国高被引学者
2024年，全球前2%顶尖科学家（World Top 2% Scientists，斯坦福大学排名）

科研项目代表性学术论文

1. Xueze Zhao,† Jiangping Liu† (†equal contributors), Jiangli Fan*, Hui Chao*, Xiaojun Peng, “Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application”, Chem. Soc. Rev., 50 (2021) 4185-4219.
2. Leli Zeng, Pranav Gupta, Yanglu Chen, Enju Wang, Liangnian Ji, Hui Chao*, Zhe-Sheng Chen*, "The development of anticancer ruthenium(II) complexes: from single molecule compounds to nanomaterials", Chem. Soc. Rev., 46 (2017) 5771-5804. (Inside front cover)
3. Tao Feng, Johannes Karges, Xinxing Liao, Liangnian Ji, Hui Chao*, “Engineered Exosomes as a Natural Nanoplatform for Cancer Targeted Delivery of Metal-Based Drugs”, Coord. Chem. Rev., 454 (2022) 214325.
4. Jinchao Shen, Thomas W Rees, Liangnian Ji, Hui Chao*, “Recent advances in ruthenium(II) and iridium(III) complexes containing nanosystems for cancer treatment and bioimaging”, Coord. Chem. Rev., 443 (2021) 214016.
5. Fangmian Wei†, Thomas W. Rees† (†equal contributors), Xinxing Liao, Liangnian Ji, Hui Chao*, “Oxygen self-sufficient photodynamic therapy”, Coord. Chem. Rev., 432 (2021) 213714.
6. Kangqiang Qiu, Hongyi Zhu, Thomas W. Rees, Liangnian Ji, Qianling Zhang*, Hui Chao*, “Recent advances in lysosome-targeting luminescent transition metal complexes”, Coord. Chem. Rev., 398 (2019) 113010.
7. Kangqiang Qiu, Yu Chen, Thomas W. Rees, Liangnian Ji, Hui Chao*, “Organelle-targeting metal complexes: From molecular design to bio-applications”, Coord. Chem. Rev., 378 (2019) 66-86.
8. Jiangping Liu, Chen Zhang, Thomas W. Rees, Libing Ke, Liangnian Ji, Hui Chao*, “Harnessing ruthenium(II) as photodynamic agents: encouraging advances in cancer therapy”, Coord. Chem. Rev., 363 (2018) 17–28.
9. Yu Chen†, Ruilin Guan† (†equal contributors), Chen Zhang, Juanjuan Huang, Liangnian Ji, Hui Chao∗, “Two-photon luminescent metal complexes for bioimaging and cancer phototherapy”, Coord. Chem. Rev., 310 (2016) 16-40.
10. Guanying Li, Ruilin Guan, Liangnian Ji, Hui Chao*, “DNA condensation induced by metal complexes”, Coord. Chem. Rev., 281 (2014) 100-113. 
11. Kai Xiong, Fangmian Wei, Yu Chen*, Liangnian Ji, Hui Chao*, “Recent Progress in Photodynamic Immunotherapy with Metal-Based Photosensitizers”, Small Methods, 7 (2023) 2201403.
12. Yu Chen, Thomas W. Rees, Liangnian Ji, Hui Chao*, “Mitochondrial dynamics tracking with iridium(III) complexes”, Curr. Opin. Chem. Biol., 43 (2018) 51-57.
13. Huaiyi Huang†, Samya Banerjee† (†equal contributors), Kangqiang Qiu, Pingyu Zhang, Olivier Blacque,Thomas Malcomson, Martin J. Paterson, Guy J. Clarkson, Michael Staniforth, Vasilios G. Stavros, Gilles Gasser*, Hui Chao*, Peter J. Sadler*, “Targeted photoredox catalysis in cancer cells”, Nat. Chem., 11 (2019) 1041-1048.
14. Johannes Karges, Shi Kuang, Federica Maschietto, Olivier Blacque, Ilaria Ciofini, Hui Chao*, Gilles Gasser*, “Rationally Designed Ruthenium Complexes for 1- and 2-Photon Photodynamic Therapy”, Nat. Commun., 11 (2020) 3262.
15. Zhixuan Zhou†, Jiangping Liu† (†equal contributors), Juanjuan Huang, Thomas W. Rees, Heng Wang, Xiaopeng Li, Hui Chao*, Peter J. Stang*, “A self-assembled Ru-Pt metallacage as a lysosome-targeting photosensitizer for two-photon photodynamic therapy”, Proc. Natl, Acad. Sci. USA, 116 (2019) 20296-20302.
16. Zhixuan Zhou†, Jiangping Liu† (†equal contributors), Thomas W. Rees, Heng Wang,Xiaopeng Li, Hui Chao*, Peter J. Stang*, “A Heterometallic Ru-Pt Metallacycle for Two-Photon Photodynamic Therapy”, Proc. Natl, Acad. Sci. USA, 115 (2018) 5664-5669.
17. Shi Kuang†, Fangmian Wei† (†equal contributors), Johannes Karges, Libing Ke, Kai Xiong, Xinxing Liao, Gilles Gasser*, Liangnian Ji, Hui Chao*, “Photo-Decaging of A Mitochondria-Localized Iridium(III) Endoperoxide Complex for Two-Photon Photoactivated Therapy under Hypoxia”, J. Am. Chem. Soc., 144 (2022) 4091−4101.
18. Tao Feng, Zixin Tang, Jun Shu, Xianbo Wu, Hui Jiang, Zhuoli Chen, Yu Chen, Liangnian Ji, Hui Chao*, “A Cyclometalated Ruthenium(II) Complex Induces Oncosis for Synergistic Activation of Innate and Adaptive Immunity”, Angew. Chem. Int. Ed., 63 (2024) e202405679.
19. Shi Kuang, Biyue Zhu, Jing Zhang, Fan Yang, Bo Wu, Weihua Ding, Liuyue Yang, Shiqian Shen, Seven H Liang, Prasenjit Mondal, Mohanraja Kumar, Rudolph E. Tanzi, Can Zhang, Hui Chao*, Chongzhao Ran*, “A Photolabile Curcumin-Diazirine Analogue Enables Phototherapy with Physically and Molecularly Produced Light for Treatment of Alzheimer's Disease”, Angew. Chem. Int. Ed., 62 (2023) e202312519.
20. Asma Mani†, Tao Feng†, Albert Gandioso†, Robin Vinck† (†equal contributors), Anna Notaro, Lisa Gourdon, Pierre Burckel, Bruno Saubaméa, Olivier Blacque, Kevin Cariou, Jamel-Eddine Belgaied, Hui Chao,* Gilles Gasser,* “Structurally Simple Osmium(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy in the Near Infrared”, Angew. Chem. Int. Ed., 62 (2023) e202218347.
21. Kai Xiong†, Cheng Ouyang† (†equal contributors), Jiaqi Liu, Johannes Karges, Xinlin Lin, Xiang Chen, Yu Chen*, Jian Wan*, Liangnian Ji, Hui Chao*, “Chiral Ru^II-Pt^II Complexes Inducing Telomere Dysfunction against Cisplatin-Resistant Cancer Cells”, Angew. Chem. Int. Ed., 61 (2022) e202204866.
22. Libing Ke†, Fangmian Wei† (†equal contributors), Lina Xie, Johannes Karges, Yu Chen, Liangnian Ji, Hui Chao*, “A Biodegradable Iridium(III) Coordination Polymer for Enhanced Two-Photon Photodynamic Therapy using an Apoptosis-Ferroptosis Hybrid Pathway”, Angew. Chem. Int. Ed., 61 (2022) e202205429. (Hot Paper)
23. Chengzhi Jin, Guanying Li, Xia Wu, Jiangpin Liu, Weijun Wu, Toshio Sasaki, Hui Chao*, Ye Zhang*, “Robust Packing of a Self-Assembling Iridium Complex via Endocytic Trafficking for Long-Term Lysosome Tracking”, Angew. Chem. Int. Ed., 60 (2021) 7597-7601.
24. Lili Wang, Ruilin Guan, Lina Xie, Xinxing Liao, Kai Xiong, Thomas W. Rees, Yu Chen, Liangnian Ji, Hui Chao*, “An ER-Targeting Iridium(III) Complex which Induces Immunogenic Cell Death in Non-Small Cell Lung Cancer”, Angew. Chem. Int. Ed., 60 (2021) 4657-4665. (VIP Article)
25. Cheng Ouyang, Yongguang Li, Thomas W. Rees, Xinxing Liao, Jianhua Jia, Yu Chen*, Xiting Zhang*, Liangnian Ji, Hui Chao*, “Supramolecular Assembly of An Organoplatinum(II) Complex with Ratiometric Dual Emission for Two-Photon Bioimaging”, Angew. Chem. Int. Ed., 60 (2021) 4150-4157.
26. Shi Kuang†, Lingli Sun† (†equal contributors), Xianrui Zhang, XinXing Liao, Thomas W. Rees, Leli Zeng, Yu Chen*, Xiting Zhang*, Liangnian Ji, Hui Chao*, “A Mitochondrion-Localized Two-Photon Photosensitizer Generating Carbon Radicals against Hypoxic Tumors”, Angew. Chem. Int. Ed., 59 (2020) 20697-20703.
27. Kai Xiong, Chen Qian, Yixian Yuan, Lin Wei, Xinxing Liao, Liting He, Thomas W. Rees, Yu Chen*, Jian Wan*, Liangnian Ji, Hui Chao*, “Necroptosis Induced by Ruthenium(II) Complexes as Dual Catalytic Inhibitors of Topoisomerase I/II”, Angew. Chem. Int. Ed., 59 (2020) 16631-16637. (Hot Paper)
28. Chengzhi Jin†, Fengyin Liang† (†equal contributors), Jinquan Wang, Lili Wang, Jiangping Liu, Xinxing Liao, Thomas W. Rees, Bo Yuan, Hui Wang, Yong Shen*, Zhong Pei*, Liangnian Ji, Hui Chao*, “Rational Design of Cyclometalated Iridium(III) Complexes for Three-Photon Phosphorescence Bioimaging”, Angew. Chem. Int. Ed., 59 (2020) 15987-15991. (Hot Paper)
29. Shi Kuang, Xinxing Liao, Xianrui Zhang, Thomas W. Rees, Ruilin Guan, Kai Xiong, Yu Chen*, Liangnian Ji, Hui Chao*, “FerriIridium: A Lysosome-Targeting Iridium(III) Prodrug for Iron(III)-Activated Chemotherapy in Gastric Cancer Cells”, Angew. Chem. Int. Ed., 59 (2020) 3315-3321.（ (VIP Article)
30. Johannes Karges, Uttara Basu, Olivier Blacque, Hui Chao*, Gilles Gasser*, “Polymeric encapsulation of novel homoleptic bis(dipyrrinato) zinc(II) complexes with long lifetimes for applications as photodynamic therapy photosensitisers”, Angew. Chem. Int Ed., 58 (2019) 14334-14340.
31. Pingyu Zhang†, Cookson K. C. Chiu† (†equal contributors), Huaiyi Huang, Yuko P. Y. Lam, Abraha Habtemariam, Thomas Malcomson, Martin J. Paterson, Guy J. Clarkson, Peter B. O’Connor*, Hui Chao*, Peter J. Sadler*, "Organo-iridium photosensitizers can induce specific oxidative attack on proteins in cancer cells", Angew. Chem. Int. Ed., 56 (2017) 14898-14902. （(VIP Article, Inside front cover)
32. Huaiyi Huang†, Bole Yu† (†equal contributors), Pingyu Zhang, Juanjuan Huang, Yu Chen, Gilles Gasser*, Liangnian Ji, Hui Chao*, “Highly charged ruthenium(II) polypyridyl complexes as lysosome-localized photosensitizers for two-photon photodynamic therapy”, Angew. Chem. Int. Ed., 54 (2015) 14049-14052. (VIP Article)
33. Jia Li, Leli Zeng*, Zheng Wang, Hengxing Chen, Shuo Fang, Jinquan Wang, Chao-Yun Cai, Enming Xing, Xinxing Liao, Zhi-Wei Li, Charles R. Ashby Jr, Zhe-Sheng Chen*, Hui Chao*, Yihang Pan*, “Cycloruthenated Self-Assembly with Metabolic Inhibition to Efficiently Overcome Multidrug Resistance in Cancers”, Adv. Mater., 34 (2022) 2100245.
34. Fangmian Wei, Johannes Karges, Siyuan Gao, Lili Wang, Xiting Zhang*, Xing-Can Shen*, Liangnian Ji, Hui Chao*, “Two-Photon Phototriggering of ROS Storm in Ruthenium(II) Coordinated Carbon Nitride for Robust Cancer Immunotherapy”, Nano Today, 54 (2024) 102066.
35. Fangmian Wei, Johannes Karges, Jinchao Shen, Lina Xie, Kai Xiong, Xiting Zhang*, Liangnian Ji, Hui Chao*, “A Mitochondria-Localized Oxygen Self-SufficientTwo-Photon Nano-Photosensitizer for Ferroptosis-Boosted Photodynamic Therapy under Hypoxia”, Nano Today, 44 (2022) 101509.
36. Fangmian Wei†, Jinzhe Liang† (†equal contributors), Zhushuang Tan, Shunxin Tang, Han Xu, Hong Liang*, Xing-Can Shen*, Hui Chao*, “Rhenium(I) Coordinated Carbon Nitride as Type II Immunogenic Cell Death Inducers for Enhancing Photoimmunotherapy against Triple-Negative Breast Cancer”, Chem. Eng. J., 485 (2024) 150154.
37. Tao Feng, Zixin Tang, Johannes Karges, Jinchao Shen, Chengzhi Jin. Yu Chen, Yihang Pan,* Yulong He,* Liangnian Ji, Hui Chao*, “Exosome Camouflaged Coordination-Assembled Iridium(III) Photosensitizers for Apoptosis-Autophagy-Ferroptosis Induced Combination Therapy against Melanoma”, Biomaterials, 301 (2023) 122212.
38. Fangmian Wei, Shi Kuang, Thomas W. Rees, Xinxing Liao, Jiangping Liu, Diqing Luo, Jinquan Wang*, Xiting Zhang*, Liangnian Ji, Hui Chao*, “Ruthenium(II) Complexes Coordinated to Graphitic Carbon Nitride: Oxygen Self-Sufficient Photosensitizers Which Produce Multiple ROS for Photodynamic Therapy in Hypoxia”, Biomaterials, 276 (2021) 121064.

39. Jinchao Shen, Johannes Karges, Kai Xiong, Yu Chen, Liangnian Ji, Hui Chao*, “Cancer Cell Membrane Camouflaged Iridium Complexes Functionalized Black-Titanium Nanoparticles for Hierarchical-Targeted Synergistic NIR-II Photothermal and Sonodynamic Therapy”, Biomaterials, 275 (2021) 120979.

40. Jinchao Shen, Thomas W. Rees, Zhiguo Zhou*, Shiping Yang*, Liangnian Ji, Hui Chao*, “A Mitochondria-Targeting Magnetothermogenic Nanozyme for Magnet-Induced Synergistic Cancer Therapy”, Biomaterials, 251 (2020) 120079.
41. Qixin Chen†, Xintian Shao†, Mingang Hao† (†equal contributors), Hongbao Fang, Ruilin Guan, Zhiqi Tian, Miaoling Li, Chenran Wang, Liangnian Ji, Hui Chao*, Jun-Lin Guan*, Jiajie Diao*, “Quantitative Analysis of Interactive Behavior of Mitochondria and Lysosomes Using Structured Illumination Microscopy”, Biomaterials, 250 (2020) 120059.
42. Huaiyi Huang†, Liang Yang† (†equal contributors), Pingyu Zhang, Kangqiang Qiu, Juanjuan Huang, Yu Chen, Jiajie Diao, Jiankang Liu, Liangnian Ji, Jiangang Long*, Hui Chao*, "Real-time tracking mitochondrial dynamic remodeling with two-photon phosphorescent iridium (III) complexes", Biomaterials, 83 (2016) 321-331.
43. Pingyu Zhang†, Jinquan Wang† (†equal contributors), Huaiyi Huang, Bole Yu, Kangqiang Qiu, Juanjuan Huang, Shutao Wang, Lei Jiang, Gilles Gasser, Liangnian Ji, Hui Chao*, “Unexpected high photothemal conversion efficiency of gold nanospheres upon grafting with two-photon luminescent ruthenium(II) complexes: a way towards cancer therapy?”, Biomaterials, 63 (2015) 102-114.
44. Guanying Li, Yu Chen, Jinquan Wang, Jingheng Wu, Gilles Gasser, Liangnian Ji, Hui Chao*, “Direct imaging of biological sulfur dioxide derivatives in vivo using a two-photon phosphorescent probe”, Biomaterials, 63 (2015) 128-136.
45. Xiang Chen, Lingli Sun, Yu Chen, Xiaolin Cheng, Weijun Wu, Liangnian Ji, Hui Chao*, “A fast and selective two-photon phosphorescent probe for the imaging of nitric oxide in mitochondria”, Biomaterials, 58 (2015) 72-81.
46. Jiangping Liu, Yu Chen, Guanying Li, Pingyu Zhang, Chengzhi Jin, Leli Zeng, Liangnian Ji, Hui Chao*, "Ruthenium(II) polypyridyl complexes as mitochondria-targeted two-photon photodynamic anticancer agents", Biomaterials, 56 (2015) 140-153.
47. Pingyu Zhang†, Huaiyi Huang† (†equal contributors), Yu Chen, Jinquan Wang, Liangnian Ji, Hui Chao*, “Ruthenium(II) anthraquinone complexes as two-photon luminescent probes for cycling hypoxia imaging in vivo”, Biomaterials, 53 (2015) 522-531.
48. Guanying Li†, Qian Lin† (†equal contributors), Lingli Sun, Changsheng Feng, Pingyu Zhang, Bole Yu, Yu Chen, Ya Wen, Hui Wang, Liangnian Ji, Hui Chao*, “A mitochondrial targeted two-photon iridium(III) phosphorescent probe for selective detection of hypochlorite in live cells and in vivo”, Biomaterials, 53 (2015) 285-295.
49. Pingyu Zhang†, Jinquan Wang† (†equal contributors), Huaiyi Huang, Hongmin Chen, Ruilin Guan, Yu Chen, Liangnian Ji, Hui Chao*, “RuNH₂@AuNPs as two-photon luminescent probes for thiols in living cells and tissues”, Biomaterials, 35 (2014) 9003-9011.
50. Yu Chen†, Liping Qiao† (†equal contributors), Liangnian Ji, Hui Chao*, “Phosphorescent iridium(III) complexes as multicolor probes for specific mitochondrial imaging and tracking”, Biomaterials, 35 (2014) 2-13. 
51. Qixin Chen†, Chengzhi Jin†, Xintian Shao†, Ruilin Guan† (†equal contributors), Zhiqi Tian, Chenran Wang, Fei Liu, Peixue Ling, Jun-Lin Guan, Liangnian Ji, Fengshan Wang*, Hui Chao*, Jiajie Diao*, “Super-Resolution Tracking of Mitochondrial Dynamics with An Iridium(III) Luminophore”, Small, 41 (2018) 1802166.
52. Kai Xiong, Xinlin Lin, Junfeng Kou, Fangmian Wei,  Jinchao Shen, Yu Chen*, Liangnian Ji, Hui Chao*, “Apoferritin-Cu(II) Nanoparticles Induce Oncosis in Multidrug-Resistant Colon Cancer Cells”, Adv. Healthcare Mater., 13 (2024) 2302564.
53. Tao Feng, Zixin Tang, Johannes Karges, Jun Shu, Kai Xiong, Chengzhi Jin, Yu Chen, Gilles Gasser*, Liangnian Ji, Hui Chao*, “An iridium(III)-based photosensitizer disrupting the mito-chondrial respiratory chain induces ferritinophagy-mediated immunogenic cell death”, Chem. Sci., 15 (2024) 6752–6762.
54. Fangmian Wei, Libing Ke, Siyuan Gao, Johannes Karges, Jinquan Wang, Yu Chen, Liangnian Ji, Hui Chao*, “In-situ oxidative polymerization of platinum(IV) prodrugs in pore-confined spaces of CaCO₃ nanoparticles for cancer chemoimmunotherapy”, Chem. Sci., 14 (2023) 7005–7015.
55. Lili Wang, Johannes Karges, Fangmian Wei, Lina Xie, Zhuoli Chen, Gilles Gasser*, Liangnian Ji, Hui Chao*, “A mitochondria-localized iridium(III) photosensitizer for two-photon photodynamic immunotherapy against melanoma”, Chem. Sci., 14 (2023) 1461-1471.
56. Ruilin Guan, Yu Chen, Leli Zeng, Thomas W. Rees, Chengzhi Jin, Juanjuan Huang, Zhe-Sheng Chen, Liangnian Ji, Hui Chao*, “Oncosis-inducing cyclometalated iridium(III) complexes”, Chem. Sci., 9 (2018) 5183–5190.
57. Guanying Li, Yu Chen, Jinquan Wang, Qian Lin, Jing Zhao, Liangnian Ji, Hui Chao*, “A dinuclear iridium(III) complex as a visual specific phosphorescent probe for endogenous sulphite and bisulphite in living cells”, Chem. Sci., 4 (2013) 4426-4433.
58. Kai Xiong†, Ying Zhou† (†equal contributors), Johannes Karges, Kejie Du, Jinchao Shen, Mingwei Lin, Fangmian Wei, Junfeng Kou, Yu Chen*, Liangnian Ji, Hui Chao*, “Autophagy-Dependent Apoptosis Induced by Apoferritin-Cu(II) Nanoparticles in Multidrug Resistant Colon Cancer Cells”, ACS Appl. Mater. Interfaces, 13 (2021) 38959-38968.
59. Johannes Karges†, Jia Li† (†equal contributors), Leli Zeng, Hui Chao*, Gilles Gasser*, “Polymeric Encapsulation of a Ruthenium Polypyridine Complex for Tumour Targeted 1- and 2-Photon Photodynamic Therapy”, ACS Appl. Mater. Interfaces, 12 (2020) 54433-54444.
60. Zhou Liu†, Lina Xie† (†equal contributors),Kangqiang Qiu, Xinxing Liao, Thomas W. Rees, Zizhuo Zhao*, Liangnian Ji, Hui Chao*, “An Ultra-Small RuO₂ Nanozyme which Exhibits Multienzyme–Like Activity for the Prevention of Acute Kidney Injury”, ACS Appl. Mater. Interfaces, 12 (2020) 31205-31216.
61. Kangqiang Qiu, Jinquan Wang, Cuilan Song, Lili Wang, Hongyi Zhu, Huaiyi Huang, Juanjuan Huang, Hui Wang, Liangnian Ji, Hui Chao*, “Crossfire for two-photon photodynamic therapy with fluorinated ruthenium(II) photosensitizers”, ACS Appl. Mater. Interfaces, 9 (2017) 18482-18492.
62. Kangqiang Qiu, Huaiyi Huang, Bingyang Liu, Yukang Liu, Ziyi Huang, Yu Chen, Liangnian Ji, Hui Chao*, "Long-Term Lysosomes Tracking with A Water-Soluble Two-Photon Phosphorescent Iridium(III) Complex", ACS Appl. Mater. Interfaces, 8 (2016) 12702-12710.
63. Pingyu Zhang, Huaiyi Huang, Juanjuan Huang, Hongmin Chen, Jinquan Wang, Kangqiang Qiu, Donglei Zhao, Liangnian Ji, Hui Chao*, “Non-Covalent Ruthenium(II) Complexes–Single Walled Carbon Nanotube Composites for Bimodal Photothermal and Photodynamic Therapy with Near-Infrared Irradiation”, ACS Appl. Mater. Interfaces, 7 (2015) 23278-23290.
64. Kangqiang Qiu, Yang Du, Jiyan Liu, Jun-Lin Guan, Hui Chao*, Jiajie Diao*, “Super-resolution observation of lysosomal dynamics with fluorescent gold nanoparticles”, Theranostics, 10 (2020) 6072-6081.
65. Libing Ke, Fangmian Wei, Xinxing Liao, Thomas W. Rees, Shi Kuang, Zhou Liu, Yu Chen, Liangnian Ji, Hui Chao*, “Nano-assembly of ruthenium(II) photosensitizers for endogenous glutathione depletion and enhanced two-photon photodynamic therapy”, Nanoscale, 13 (2021) 7590-7599.
66. Mengsi Zheng, Xinlin Lin, Kai Xiong, Xiting Zhang*, Yu Chen*, Liangnian Ji, Hui Chao*, “A hetero-bimetallic Ru(II)-Ir(III) photosensitizer for effective cancer photodynamic therapy under hypoxia”, Chem. Commun., 60 (2024) 2776–2779.
67. Fangmian Wei, Zhuoli Chen, Xing-Can Shen*, Liangnian Ji, Hui Chao*, “Recent progress in metal complexes functionalized nanomaterials for photodynamic therapy”, Chem. Commun., 59 (2023) 6956-6968.
68. Mingwei Lin†, Shanshan Zou† (†equal contributors), Tingzhen Li, Johannes Karges, Yu Chen*, Yukun Zhao*, Liangnian Ji, Hui Chao*, “Chiral rhodium(III)-azobenzene complexes as photoswitchable DNA molecular locks”, Chem. Commun., 58 (2022) 4324-4327.
69. Liting He, Kai Xiong, Lili Wang, Ruilin Guan*, Yu Chen*, Liangnian Ji, Hui Chao*, “Iridium(III) complexes as mitochondrial topoisomerase inhibitors against cisplatin-resistant cancer cells”, Chem. Commun., 57 (2021) 8308–8311.

70. Mingwei Lin, Shanshan Zou, Xinxing Liao, Yu Chen*, Diqing Luo*, Liangnian Ji, Hui Chao*, “Ruthenium(II) complexes as bioorthogonal two-photon photosensitizers for tumour-specific photodynamic therapy against triple-negative breast cancer cells”, Chem. Commun., 57 (2021) 4408-4411.

71. Liping Qiao, Jiangping Liu*, Yunhong Han, Fangmian Wei, Xinxing Liao, Cheng Zhang, Lina Xie, Liangnian Ji, Hui Chao*, “Rational design of a lysosome-targeting and near-infrared absorbing Ru(II)-BODIPY conjugate for photodynamic therapy”, Chem. Commun., 57 (2021) 1790-1793.
72. Jiangping Liu, Xinxing Liao, Kai Xiong, Shi Kuang, Chengzhi Jin, Liangnian Ji, Hui Chao*, “Boosting two-photon photodynamic therapy with mitochondria-targeting ruthenium-glucose conjugates”, Chem. Commun., 56 (2020) 5839-5842.
73. Zhou Liu, Kangqiang Qiu, Xinxing Liao, Thomas W. Rees, Yu Chen*, Zizhuo Zhao*, Liangnian Ji, Hui Chao*, “Nucleus-targeting ultrasmall ruthenium(IV) oxide nanoparticles for photoacoustic imaging and low temperature photothermal therapy in the NIR-II window”, Chem. Commun., 56 (2020) 3019-3022.
74. Cheng Zhang, Ruilin Guan, Xinxing Liao, Cheng Ouyang, Thomas W. Rees, Jiangping Liu, Yu Chen*, Liangnian Ji, Hui Chao*, “A mitochondria-targeting dinuclear Ir-Ru complex as a synergistic photoactivated chemotherapy and photodynamic therapy agent against cisplatin-resistant tumour cells”, Chem. Commun., 55 (2019) 12547-12550.
75. Kangqiang Qiu†, Ya Wen† (†equal contributors), Cheng Ouyang, Xinxing Liao, Chaofeng Liu, Thomas W. Rees, Qianling Zhang*, Liangnian Ji, Hui Chao*, “The stepwise photodamage of organelles by two-photon luminescent ruthenium(II) photosensitizers “, Chem. Commun., 55 (2019) 11235-11238.
76. Jia Li, Leli Zeng, Kai Xiong, Thomas W. Rees, Chengzhi Jin, Weijun Wu, Yu Chen*, Liangnian Ji, Hui Chao*, “A biotinylated ruthenium(II) photosensitizer for tumor-targeted two-photon photodynamic therapy”, Chem. Commun., 55 (2019) 10972-10975.
77. Libing Ke†, Cheng Zhang† (†equal contributors), Xinxing Liao, Kangqiang Qiu, Thomas W. Rees, Yu Chen*, Zizhuo Zhao*, Liangnian Ji, Hui Chao*, “Mitochondria-targeted Ir@AuNRs as bifunctional therapeutic agents for hypoxia imaging and photothermal therapy”, Chem. Commun., 55 (2019) 10273-10276.
78. Zhou Liu, Jinquan Wang, Kangqiang Qiu, Xinxing Liao, Thomas W. Rees, Liangnian Ji, Hui Chao*, “Fabrication of red blood cell membrane-camouflaged Cu_2-xSe nanoparticles for phototherapy in the second near-infrared window”, Chem. Commun., 55 (2019) 6523-6526.
79. Leli Zeng†, JiaLi† (†equal contributors), Chen Zhang, Yun-Kai Zhang, Wei Zhang, Juanjuan Huang, Charles R. Ashby Jr, Zhe-Sheng Chen*, Hui Chao*, “An organoruthenium complex overcomes ABCG2-mediated multidrug resistance via multiple mechanisms”, Chem. Commun., 55 (2019) 3833-3836.
80. Kangqiang Qiu†, Jinquan Wang† (†equal contributors), Thomas W. Rees, Liangnian Ji, Qianling Zhang*, Hui Chao*, “A mitochondria-targeting photothermogenic nanozyme for MRI-guided mild photothermal therapy”, Chem. Commun., 54 (2018) 14108-14111.
81. Cheng Ouyang, Lei Chen, Thomas W. Rees, Yu Chen* Jiankang Liu, Liangnian Ji, Jiangang Long*, Hui Chao*, “A mitochondria-targeting hetero-binuclear Ir(III)-Pt(II) complex induces necrosis in cisplatin-resistant tumor cells”, Chem. Commun., 54 (2018) 6268-6271.

82. Kangqiang Qiu†, Libing Ke† (†equal contributors), Xuepeng Zhang, Yukang Liu, Thomas W. Rees, Liangnian Ji, Jiajie Diao*, Hui Chao*, “Tracking mitochondrial pH fluctuation during cell apoptosis with two-photon phosphorescent iridium(III) complexes”, Chem. Commun., 54 (2018) 2421-2424.

83. Pingyu Zhang*, Yi Wang, Kangqiang Qiu, Zhiqian Zhao, Rentao Hu, Chuanxin He, Qianling Zhang*, Hui Chao*, “NIR phosphorescent osmium(II) complex as lysosome tracking reagent and photodynamic therapeutics”, Chem. Commun., 53 (2017) 12341-12344.
84. Chengzhi Jin, Ruilin Guan, Jingheng Wu, Bo Yuan, Lili Wang, Juanjuan Huang, Hui Wang, Liangnian Ji, Hui Chao*, “Rational design of NIR-emitting iridium(III) complexes for multimodal phosphorescence imaging of mitochondria under two-photon excitation”, Chem. Commun., 53 (2017) 10374-10377.
85. Jiangping Liu, Chengzhi Jin, Bo Yuan, Yu Chen, Xingguo Liu, Liangnian Ji, Hui Chao*, “Enhanced cancer therapy by marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(III) complexes”, Chem. Commun., 53 (2017) 9878-9881.
86. Jiangping Liu†, Chengzhi Jin† (†equal contributors), Bo Yuan, Xingguo Liu, Yu Chen, Liangnian Ji, Hui Chao*, “Selectively Lighting Up Two-Photon Photodynamic Activity in Mitochondria with AIE-Active Iridium(III) Complexes”, Chem. Commun., 53 (2017) 2052-2055.
87. Leli Zeng†, Shi Kuang† (†equal contributors), Guanying Li, Chengzhi Jin, Liangnian Ji, Hui Chao*, “A GSH-activatable ruthenium(II)-azo photosensitizer for two-photon photodynamic therapy”, Chem. Commun., 53 (2017) 1977-1980.
88. Bole Yu, Ying Chen, Mei Hong, Pingping Duan, Shifeng Gan, Hui Chao*, Zujin Zhao*, Jing Zhao*, "Rhodium-catalyzed C–H activation of hydrazines leads to isoquinolones with tunable aggregation-induced emission properties", Chem Commun., 51 (2015) 14365-14368.
89. Wenchao Xu, Jiarui Zuo, Lili Wang, Liangnian Ji, Hui Chao*, “Dinuclear ruthenium(II) polypyridyl complexes as single and two-photon luminescence cellular imaging probes”, Chem. Commun., 50 (2014) 2123-2125.
90. Yu Chen†, Liping Qiao† (†equal contributors), Bole Yu, Guanying Li, Chunyuan Liu, Liangnian Ji, Hui Chao*, “Mitochondria-specific phosphorescent imaging and tracking in living cells with an AIPE-active iridium(III) complex”, Chem. Commun., 49 (2013) 11095-11097.
91. Guanying Li, Yu Chen, Jingheng Wu, Liangnian Ji, Hui Chao*, “Thiol-specific phosphorescent imaging in living cells with an azobis(2,2¢-bipyridine)-bridged dinuclear iridium(III) complex”, Chem. Commun., 49 (2013) 2040-2042.
92. Bole Yu, Yu Chen, Cheng Ouyang, Huaiyi Huang, Liangnian Ji, Hui Chao*, “A luminescent tetranuclear ruthenium(II) complex as a tracking non-viral gene vector”, Chem. Commun., 49 (2013) 810-812.
93. Guo-Liang Liao, Xiang Chen, Liang-Nian Ji, Hui Chao*, “Visual specific luminescent probing of hybrid G-quadruplex DNA by a ruthenium polypyridyl complex”, Chem. Commun., 48 (2012) 10781-10783.
94. Yuxin Wen†, Xianbo Wu†, Weijun Wu† (†equal contributors), Tao Feng, Yihang Pan*, Yulong He*, Liangnian Ji, Hui Chao*, “A Mitochondrial-Targeted Nitric Oxide Probe for Multimodality Imaging of Macrophage Immune Responses”, Anal. Chem., 96 (2024) 6666-6673.
95. Weijun Wu†, Yuxin Wen† (†equal contributors), Yu Chen, Liangnian Ji, Hui Chao*, “A Mitochondria-Localized Iridium(III) Complex for Simultaneous Two-Photon Phosphorescence Lifetime Imaging of Downstream Products N₂O₃ and ONOO^- of Endogenous Nitric Oxide”, Anal. Chem., 95 (2023) 15956-15964.
96. Weijun Wu†, Xinxing Liao† (†equal contributors), Yu Chen,Liangnian Ji, Hui Chao*, “A Mitochondria-Targeting and Reversible Near-Infrared Emissive Iridium(III) Probe for in vivo ONOO^-/GSH Redox Cycles Monitoring”, Anal. Chem., 93 (2021) 8062-8070.

97. Weijun Wu†, Cheng Zhang† (†equal contributors), Thomas W. Rees, Xinxing Liao, Xu Yan, Yu Chen, Liangnian Ji, Hui Chao*, “A Lysosome-Targeting Iridium(III) Probe with Near-Infrared Emission for The Visualization of NO/O₂^•- Crosstalk via in vivo Peroxynitrite Imaging”, Anal. Chem., 92 (2020) 6003-6009.

98. Weijun Wu, Ruilin Guan, Xinxing Liao, Xu Yan, Thomas W. Rees, Liangnian Ji, Hui Chao*, “Bimodal Visualization of Endogenous Nitric Oxide in Lysosomes with A Two-Photon Iridium(III) Phosphorescent Probe”, Anal. Chem., 91 (2019) 10266-10272.
99. Xinlin Lin, Mengsi Zheng, Kai Xiong, Fa Wang, Yu Chen*, Liangnian Ji, Hui Chao*, “Two-Photon Photodegradation of E3 Ubiquitin Ligase Cereblon by a Ru(II) Complex: Inducing Ferroptosis in Cisplatin-Resistant Tumors Cells”, J. Med. Chem., 67 (2024) 8372-8382.
100. Huaiyi Huang, Pingyu Zhang, Bole Yu, Yu Chen, Jinquan Wang, Liangnian Ji and Hui Chao*, "Targeting Nucleus DNA with a Cyclometalated Dipyridophenazine Ruthenium(II) Complex", J. Med. Chem., 57 (2014) 8971-8983. (Highlight as Highly Cited Article of 2014 of J Med Chem)
101. Xiaoda Song, Yong Qian, Rong Ben, Xiang Lu, Hai-Liang Zhu*, Hui Chao* and Jing Zhao*, “Activation of C−H bonds in nitrones leads to iridium hydrides with antitumor activity”, J. Med. Chem., 56 (2013) 6531-6535.